Klimenko K. Diabetic angiopathy correction using liposomal quercetin and inhibition of proteinkinase C gene expression on posttranscriptional level

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U001301

Thesis Registration Form

0415U001301.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

04-02-2015

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The dissertation is devoted to experimental investigation of alfa and delta PKC isozymes role in diabetic vascular endothelium dysfunction and potassium channelopathy and to the efficacy of PKC genes silencing and quercetin-filled liposomes (lipoflavon) treatment on diabetic angiopathy. RNA-interference and lipoflavon appeared to have restoring effect on endothelial function, potassium channels of vascular SMCs function and possess the ability to normalize vascular redox status. This defines lipoflavon treatment and using siRNAs as a good therapeutic tool for pharmacological correction of diabetic vascular complications.

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Files

aref.doc

aref.doc

dis.doc

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