Marynych L. Cerebrum protective properties of new derivatives of 6-substituted 3R-2H- [1,2,4] triazine [2,3-c] quinazolin-2-on (experimental study).

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U003443

Thesis Registration Form

0415U003443.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

20-05-2015

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The thesis is devoted to studying the neuron protective properties of new derivatives of 6-substituted 3R-2H- [1,2,4] triazine [2,3-c] quinazolin-2-on in terms of acute cerebrovascular accidents experimental modeling. MT-279 compound (10 mg/kg) injection into rats with acute cerebrovascular accident (nonreversible bilateral occlusion of the common carotid artery) prevented the mortality of animals during the critical period of the experiment. Practically the Compound MT-279 results can be compared to mexidol drug (100 mg/kg) and are superior to piracetam (100 mg/kg). Therapeutic effect of the compound MT-279 in acute cerebrovascular accident treatment is shown in the cerebral blood flow restoration, energy shortage and violations of oxidant-antioxidant balance elimination, the anti-apoptotic and anti-hypoxic effects presence.

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Files

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