Zupaneys M. Search for new anti-inflammatory drugs in a series of nitro and oksamoil substituted N- phenylanthranilics acids

Three promising substances under the designation1-BYSG, 2-BYSG and1353-SGS, which showed pronounced antiexudative activity exceeding the activity of mefenamic acid and glucosamine sulfate, were identified during the screening studies of 19 first synthesized compounds.It was established thatsubstances1-BYSG, 2-BYSG and 1353-SGSshow antiexudative, antialterative, antiproliferative, antipyretic and moderate analgesic activity. According tothe results of of the second stage of the study thesubstance-leader under the designation 1-BYSGwas identified. In a detailed study of the anti-inflammatory properties of the substance1-BYSG in the development of collagen-induced arthritis in rats it was found that 1-BYSGhas a significant normalizing effect on the clinical, biochemical and morphological indicators of inflammation. Therefore,thestudies experimentally confirmed that development of the drug based on the substance 1-BYSG with anti-inflammatory and chondroprotective effectfor the use in mono and complex therapy of chronic inflammatory joint disease is promissing.