Khodakivska O. Cerebroprotective activity of the new 3,2'-spiro-pyrole-2-oxindole derivates in ischemic stroke (experimental research)"

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U005923

Thesis Registration Form

0415U005923.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

15-10-2015

Specialized Academic Board

Д 64.605.03

National University of Pharmacy

Essay

The thesis is dedicated to increase of efficacy of the secondary cerebroportection in acute cerebral ischemia by using 3,2'-spiro-pyrole-2-oxindole derivate, namely spiro[indole-3,1'-pyrrole[3,4-с] pyrrole]-5'-(4- methylphenyl)-3'-[2-(methylthio)ethyl]-3a',6a'- dihydro -2'h- spiro[indole-3,1'- pyrrole[3,4-c]pyrrole]-2,4',6'(1h,3'h,5'h)-trione (compound R-86) with modulating effect to steroid glutamate neurotoxicity. The obtained results experimentally prove the advisability of R86-based drug development for deeper investigation of its efficacy and safety as of cerebroprotector for ischemic stroke.

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Files

ТитулАвтореф.doc

автореферат 8.09.2013.doc

диссертация.doc

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