Vetrova K. Experimental evidance of the expediency of correction of the toxic effects of anticancer drugs by derivatives of glucosamine and their combination with quercetin

The dissertation work is concerned with the experimental justification of the application of glucosamine derivatives and their combination with quercetin to optimize the approaches to the prevention and correction of the toxic effects of anticancer drugs. At the advanced stages of the pharmacological study it have been found the corrective influence of glucosamine hydrochloride and combination of glucosamine hydrochloride and N-acetylglucosamine with quercetin on the cytostatic-induced toxicity (under the influence of doxorubicin, cyclophosphamide, methotrexate) in experiments on rats. Under the influence of the objects it have been observed the inhibition of the process of lipid peroxidation and displays of cytolysis, reduced inflammation and dystrophy, a significant decrease of the animals mortality (model of intoxication with doxorubicin), decrease of the immunosuppression (model of intoxication with cyclophosphamide). It have been showed the regulating effect on the process of doxorubicin-induced cell death by the investigated objects mediated with the interference in the bcl-2-dependent mechanisms of the apoptosis controls.