Pogotova G. Experimental justification of organ?protector action of synthetic and plant antioxidants? effectivity

The thesis is dedicated to an increase in an efficacy of treatment of diseases with an oxidative stress as a prevalent attribute. Ademetionin in dichloretan hepatitis normalizes the indicators of prooxidant-antioxidant homeostasis and energy metabolism in the liver, myocardium and brain. ?-3 Polyunsaturated Fatty Acid in dichloroethan hepatitis normalises the indicators of antioxidant systems and markers of oxidative modification of proteins in liver. ?-3 Polyunsaturated Fatty Acid does not influence on the indicators of energy metabolism in the liver. In the myocardium ?-3 Polyunsaturated Fatty Acid restores carboxyphenylhydrazone content and markers of energy metabolism, in particular, the content of adenosine triphosphate, pyruvate, malate. ?-3 Polyunsaturated Fatty Acid reduces the content of lactate in the myocardium. In the pathology selenit sodium restores the indicators of prooxidant-antioxidant homeostasis and energy metabolism in the liver and myocardium of rats. Silimarinum and extractum artichoke have the defense influence on the indicators of prooxidant-antioxidant homeostasis and energy metabolism.