Stashkevych M. Biochemical features of 5-fluorouracil action at various routs of administration to patients with gastric adenocarcinoma.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U003021

Thesis Registration Form

0416U003021.pdf

Applicant for

Stashkevych Maryna Anatoliyivna

Specialization

14.01.32 - Медична біохімія

Date of defense

08-04-2016

Specialized Academic Board

Д 29.600.03

Essay

Dissertation is devoted to the biochemical substantiation of 5-FU effectiveness when intra-arterial and endolymphatic routes of its administration was used. It is found that the load of cells with high doses of 5-fluorouracil leads to inhibition of its enzyme (thymidinephosphorilaze) activity in 3-3.5 times. This is after 1 hour of administration within stomach tissue. It is shown that the source of pentozophosphate for activation of 5-FU in the stomach tissues is a nucleoside thymidine instead of uridine, inosine or ribose-5-phosphate. The concentrating process of 5-fluorouracil in lymphocytes was screened in in vitro experiments and in vivo.

Thesis supervisor

Zyablicev Sergiy Volodimirivich

Official opponents

Загайко Андрій Леонідович
Непорада Каріне Степанівна

Files

aref.doc

dis.doc

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