Sydorenko A. «Antidepressant’s search among 2-oksoindolin-3-glyoxylic acid derivatives»

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U004969

Thesis Registration Form

0416U004969.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

11-11-2016

Specialized Academic Board

Д 64.605.03

National University of Pharmacy

Essay

The thesis is devoted to theoretical and experimental basis of search of 2-oksoindolin-3-glyoxylic acid substances with antidepressive activity and also definition of their possible mechanisms of the action. It was detected the most active substance (ethylic ether 4- [2-hydroksy-2-(2-okso-1,2-dihidro–indol-3-iliden)-atsetamino]-oil acid of E-38 with antidepressive action based on complex analysis of emotional and behavioral tests. E-38 increased dopaminergic neurotransmission and also decreased haloperidol catalepsy and intensified effects of apomorphin and L- dihydroxyphenylalanine. There were established serotonergic and noradrenergic components of antidepressive action of E-38 at reserpine and clonidine depression. There were shown mediator mechanisms of antidepressive action of derivative of 2-oksoindolin, that correlate with the increase of dopamine level, noradrenaline level and serotonin one and normalization of monoamine oxidase A activity.

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Files

Автореферат-Сидоренко-А.Г..pdf

Дисертація-Сидоренко-А.Г.-Полтава-31.-10.16.pdf

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