Khuari S. Search and pharmacological study of herbal hepatoprotectors for correction of liver disease (experimental research)

Thesis is devoted to experimental confirmation of the creation of new domestic hepatoprotectors based on plant extracts for correction of toxic effects of antibiotic therapy. As a result of screening research on CTC hepatitis model were selected 5 extracts-leaders at a dose of 5 mg/kg. Research of leading-extracts safety using acute toxicity study revealed, that according to conventional toxicological classification of substances at intra-gastric administration to mice and immature rats are belonging to class V of toxicity - to almost harmless substances (LD50>5000 mg/kg). Using the test-system Drosophila melanogaster Meig. In the test of calculation of recessive, sex-linked lethal mutations by the method of Meller-5 was revealed that the extract of Buple?rum aur?um 50%, in the half-lethal dose and products of its metabolism does not induce recessive, sex-linked lethal mutations. It is evidenced, that extracts of Buple?rum aur?um and Salsola Collina L., received as a water and 50% alcohol extracts, at a dose of 5 mg/kg have shown antioxidant, membrane protective, antiinflammatory, bile producing properties and revealed expediency of their further use in combination with antimicrobial drug co-trimoxazole. It was shown that the addition of extracts of Buple?rum aur?um to the co-trimoxazole is the most promising and does not significantly affect its initial antimicrobial properties