Duchenko K. Diuretic, analgesic and anti-inflammatory activity of new 1,8- disubstituted 7-alkyl-3-methylxanthine derivative

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U003437

Thesis Registration Form

0417U003437.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

05-07-2017

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The thesis is devoted to the screening and pharmacological activity upon the chemical structure establishment among 1,8-disubstituted 7-alkyl-3-methylxanthine derivatives. The compound-leader in diuretic effect - furoxan was found out; its acute toxicity was investigated. Its LD50 by intraperitoneal injection to mice and rats is 835 mg/kg and 1320 mg/kg respectively, and the ED50 with intragastric administration to rats is 25 mg/kg. It was established that the mechanism of diuretic action of furoxan is associated with moderation of mineralocorticoid activity, renin-angiotensin and kallikrein-kinin systems and prostaglandin synthesis. The role of activation of natriuretic peptide in the mechanism of diuretic effect of furoxan was devoted. It was determined that the capillaries of the glomeruli and proximal and distal tubules of the nephron are the place of supply of furoxan diuretic action.

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Files

aref.docx

dis.doc

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