Grin I. Pharmacological efficacy of Thiotriazoline ointment with silver nanoparticles in experimental thermal skin damage

A new solution of the actual problem of pharmacology is given in the thesis. The expediency of administrating ointment based on Thiotriazoline with the inclusion of SNP in thermal damage to the skin is theoretically and experimentally substantiated. The findings showed that Thiotriazoline ointment with SNP helped reduce the time of healing of a thermal burn (on the 21st day in 50%, on the 23th day in 100%, versus 35 days in the control group). Therapeutic effectiveness of this ointment was found to be higher as compared to comparator agents of Thiotriazoline ointment, methyluracil ointment and silver sulphathiazole ointment (no animals had signs of complete healing on the 21st day). The complex mechanism of the wound healing effect of Thiotriazoline ointment with SNP in thermal burn is determined by the modulating effect on the cytokine cascade, stabilization of the nitric oxide system, limitation of the increment of LPO processes and activation of the antioxidant system. According to the pharmacotherapeutic activity, the agents under investigation were arranged as follows: Thiotriazoline ointment with SNP > Thiotriazoline ointment ? sulphathiazole silver ointment ? methyluracil ointment.