Markhon N. Neuropharmacological activity of phyto-extracts and royal jelly extract under the condition of experimental metabolic syndrome

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U004299

Thesis Registration Form

0417U004299.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

15-11-2017

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The thesis is devoted to study of neuroprotective and antioxidant properties of propylene glycol extracts of natural origin under conditions of fructose induced metabolic syndrome. It was shown that propylene glycol extract of leaves of nettle reduces blood glucose level, levels of products of lipid peroxidation and oxidative modification of proteins in serum. Resveratrol caused reduction in LDL cholesterol with underlying increase in HDL cholesterol; as well as extracts of rowan fruits and royal jelly, it also has profound effects on memory in passive avoidance test, raising orienting and research activity in open field test, and has antidepressant property in Porsolt test. It was established that the effects of those extracts are more pronounced than the effect of piracetam.

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Files

aref.doc

dis.doc

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