In the dissertation, the peculiarity and inconsistency of the socio-political transformation of society, historical, political, ethnic and cultural trends in the development of the nation and statehood in Ukraine is investigated. The complexity of the transitional processes is analyzed, which, on the one hand, strengthens the regulatory role of the state, and on the other hand, the development of civil society implies the denationalization of social institutions, the reduction of state influence on them. The mechanisms of stabilization and destructiveness in the processes of the national state are investigated. Social-state, administrative, ethnic, national and regional-territorial processes in Ukraine require significant theoretical and applied study and application of European concepts of integration, decentralization, regionalization, subsidies, etc. as a means of improving the efficiency of public administration. European theories and models of integration and decentralization compete with each other, but when considered comprehensively, they allow a fresh look at the processes and frameworks of Ukraine's integration into European structures, especially in the European Union (EU). It is determined that regional integration is a special form of integration, limited by the territorial or geopolitical framework. According to the General opinion of the leading experts in this field, the most successful and dynamic regional integration is due to the efforts of the EU. Ideas, forms and trends of integrativity and decentralization have always been part of the European design. At the same time, the EU is certainly not a classic Federation or Confederation. The new European treaties marked a clear shift from an economic Confederation to a full multifunctional integration Union. This is all the more true for the EU, whose development strategy is not static, absolute, but constantly evolving and in a state of dynamic equilibrium. Thus, the EU can be called an integration Association of a new type. In this regard, it is already possible to receive some lessons of the first sprouts of EU-Ukraine integration, analyzing the regulatory and explanatory model of this process.