Buliha L. Experimental study of the use of gel with nanoparticles of silver and glucosamine to treat septic wounds

The dissertation is devoted to the experimental justification of the use of gel with nanoparticles of silver and glucosamine (NPAg+GA) to improve the efficiency of treatment wounds and infectious and inflammatory skin diseases. As a result of screening of experimental gels of different composition was determined that the most promising is a gel that contains a nanocomposite of silver with polyvinylpyrrolidone, corresponding to 0.1 % pure silver and 1.0 % glucosamine. On the model of an infected wound, this sample surpassed others in antimicrobial, antioxidant action, influence on cytokine-dependent mechanisms of inflammation regulation and histological evaluation of the quality of newly formed tissue. In-depth pharmacological study (on various models of the inflammatory and wound process), that the gel-leader is superior to the reference preparation containing 1.0% of silver sulfadiazine by the expressiveness of anti-inflammatory, antioxidant and wound healing activity has been identified. Healing effect of gel NPAg+GA is due to the multi-vector effect on the healing process: reduction of microbial contamination, suppression of the inflammatory-destructive process, acceleration of granulation and epithelization processes, which is due to the synergism of pharmacological properties its components.