The results of research of the influence of complex immune stimulating preparation «Arselan» and its modification – structured preparation «Arselan 2» on the state of vital functions of infusoria Tetrahymena pyriformis, morphological, biochemical and immunological indexes of blood of white rats, safe keeping, intensity of growth and state of nonspecific resistance of calves of suckling period of growing are presented in the dissertation.
It was determined that middle index of lethality of the young cattle in the farms of Kiev and Kharkiv regions from 2006 to 2016 was 5,5 %. Main reasons of death of calves of suckling period of growing were pathologies of digestive organs.
According to the results of sanitary-hygienic estimation of the state of microclimate of rooms for maintenance of calves the considerable variations of parameters of air in winter and in transitional time of year such as average temperature, relative humidity, microbal contamination that did not correspond to VNTP-APK-01.05 were determined. The unfavorable parameters of microclimate caused diseases of digestive and respiratory organs of calves.
The use of preparation «Arselan» stimulated the processes of vital functions of infusoria Tetrahymena pyriformis that showed up in activation of their reproduction.
According to the results of peroral double application of preparation «Arselan» to the white rats optimum dose – 1,0 ml 2% solution was set. Changes of absolute and relative mass of internal organs were unreliable. The difference of results of behavior tests between the rats of control and experimental groups was unreliable.
According to the results of the experiment on calves at the age of 5-60 days optimum dose of preparation «Arselan» and its structured modification – preparation «Arselan 2» that makes up 2,0 ml/head were determined. With the use of preparation in unstructured and structured form living mass of calves at the age of 60-days was bigger by 8,7 and 10,1 %.
Application of preparation «Arselan» to the calves in unstructured and structured form led to reliable increase of indexes of nonspecific resistance: the number of erythrocytes and hemoglobin, leucocytes, T- and В-lymphocytes, content of general protein, lizopim and serum bactericidal activity, phagocyte index, phagocytic activity, and also content of bifidobacteria in a large intestine. Deficit in the content of inorganic Phosphorus and general Calcium decreased in the blood serum of the experimental group of animals.
According to the results of comparative research of influence of preparation «Arselan» and its analogue – «Arselan 2» the increase of living mass of bull-calves at the age of 15-months by 6,3 7,8 %, and also average daily increases, slaughter output and carcass mass were determined.
Application of preparation «Arselan» and «Arselan 2» for calves in early age is economically profitable that is confirmed by the increase of level of profitability of growing of young cattle by 7,9 and 9,2 % respectively.
