Narokha V. Experimental study of the pharmacodynamics of germanium coordination compounds in case of anthracycline intoxication

The degree work is devoted to the study of cytoprotective effects of the coordination compound of germanium with nicotinic acid in chronic intoxication with an anthracycline antibiotic, doxorubicin. The main aim of our research was to search for ways to rectify violations found, as well as to protect myocardium and liver from doxorubicin toxic effects. The fact that doxorubicin toxic effects are associated with superoxide radical formation is an important argument in favour of justification for using antioxidants as agents preventing side effects. Cardio- and hepatoprotective activity of the coordination compound of germanium with niacin (MIGU-1) was realized by attenuation of oxidative stress caused by chronic intoxication with doxorubicin. The pharmacological effect of MIGU-1 exceeds the effect of reference drugs niacin and thiotriazoline. Extended understanding of the mechanisms of cytoprotective activity of coordination compounds of germanium and the scientific data regarding their safety. The dependence of the "structure-action" is established, which makes a promising goal-oriented synthesis of new substances of this series with the indicated action. Therefore, the obtained results provide a rationale for further preclinical and clinical studies of the MIGU-1 combination in order to create an effective cardioprotective and hepatoprotective drug to be used during chemotherapy with anthracycline antibiotics