Kryvoruchko T. Neurotropic effects of amantadine in combination with citicoline and glycine in conditions of experimental parkinsonism

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0419U000650

Thesis Registration Form

0419U000650.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

20-02-2019

Specialized Academic Board

Д 41.600.01

Odessa National Medical University

Essay

The thesis is devoted to the study of the neurotropic agents (citicoline and glycine) use peculiarities, as drugs for the maintenance of nonmotor manifestations of Parkinsons disease (depression, pain, sleep disturbance) under the conditions of experimental equivalents of parkinsonism against the background of amantadine based antiparksonian pharmacotherapy. On experimental model of parkinsonism clinical manifestations (akinesia, rigidity, tremor and “mixed form”) and neurotropic effects (pain, insomnia and depression) it was established that glycine at a dose of 200 mg / kg corrects neurological disorders during amantadine pharmacotherapy. The advantages of simultaneous use of glycine with amantadine are confirmed by the results of computer simulation of physicochemical interaction and determination of the glycine pharmacokinetic profile.

Read more

Files

Dis_Криворучко.pdf

autoreferat--aref_Криворучко.pdf

Similar theses

0422U100029

Sheikhali Ali Marsel

Experimental justification for the use of a new combined cream "Dermalipoin" for the treatment of purulent-inflammatory skin diseases

0422U100006

Dub Anastasiia Ihorivna

Experimental approach of the antidiabetic activity of the new phytocomposition

0421U102934

Stefaniv Ivan Volodymyrovych

Pharmacological characteristics of the new herbal medicine «Kasdent» for the treatment of inflammatory diseases of periodontium and oral mucosa

0421U102041

Prokopchuk Elena Gennadyevna

Complex compounds of Sn (IV) with salicyloylhydrazones of benzaldehydes as potential biologically active substances with anti-inflammatory, analgesic and concomitant pharmacological action

0521U101312

Nosivets Dmitriy Sergeevich

Pharmacological analysis of analgesia and chondroprotection in experimental osteoarthritis on the background of hypothyroidism