Kabachna I. Neuroprotection of anesthesia-induced brain disorders by derivatives of sulfur- and nitrogen-containing heterocycles

In recent years obvious that the Central anesthetics in addition to the main analgesic and henoheno actions cause permanent ischemia/hypoxic neuronal and neurological change and a number of neurotoxic side effects by triggering programmed neuronal death – apoptosis. It is shown that the frequency and severity of side effects of anesthesia on the Central nervous system can affect the dose of anesthetics and duration of General anesthesia. The earliest manifestation of neuronal damage, determined BY, is a disturbance of higher cortical functions in the first place, memory and cognitive processes, and the development of postoperative cognitive dysfunction (postoperative cognitive dysfunction postoperative cognitive dysfunction). The most vulnerable to the effects of General anesthetics is a function of attention, short-term memory, speed of psychomotor and cognitive reactions. However, in the literature only a few works are devoted to the application of neuroprotective drugs for the prevention and treatment of neurocognitive disorders in the postoperative period. Analysis of the results suggests that neuronal dysfunctional changes in brain tissue due to ischemic post-nasal injury, which were accompanied by activation of apoptosis processes (increase in the number of c-fos-positive cells, lowering of bcl-2 protein content) were reproduced on the models of rat ketamine and propofol anesthesia in rats, and had differences on these experimental models.