Dobrozhan Y. Sanitary and Hygienic Assessment of Chicken Manure by Antibiotic Content

In the dissertation, a sanitary-hygienic assessment of chicken manure, as well as food eggs when contaminated with antibiotics in various concentrations and combinations, the dynamics of the residual content of antibiotics of various groups during storage of the litter in mesophilic conditions are established. It was found that 38.6 % of samples from the chicken’s manure of industrial flocks of poultry farms in Ukraine contain residues of antibacterials drugs, including antibiotics – 38.2% of the total number of tested samples, and 99 % of the total number of positive ones. The main antibiotics of the chicken’s manure were drugs of tetracycline group (doxycycline) and fluoroquinolone group (enrofloxacin). The dissertation describes the results of the study and the detection of residual amounts of antimicrobials in selected samples of litter, as well as the results of the dynamics of antibacterial drugs when storing litter in mesophilic conditions for 17 months. It has been established that ingestion of doxycycline to chickens of industrial flocks in therapeutic and prophylactic doses influences on the duration of its excretion in eggs and litter. The residual doxycycline content of blood, eggs, and chickens’ manure during the watering period had a large range of fluctuations due to its absorption characteristics in the digestive apparatus and its high ability to bind to plasma proteins. At the prophylactic dose, complete withdrawal of doxycycline with laying hens’ manure was 21 days, and at the therapeutic dose – 28 days. The excretion of doxycycline in the composition of eggs is not significantly dependent on the dose of antibiotic in drinking water and is 15-16 days. The obtained experimental data give reason to not recommend the storage of chicken litter by the mesophilic method when using antibiotics, especially in their various combinations.