Feshchenko H. Pharmacological substantiation for the use of Chamerion angustifolium extract as an antiulcer agent

The thesis of Feshchenko H.I. is devoted to the experimental study of the chemical composition of the fireweed (Chamerion angustifolium) herb and lyophilized extract (LEFH) obtained from the studied herb and its pharmacological activity was researched. It was established that LEFH contains a significant amount of phenolic compounds (flavonoids, hydroxycinnamic acids, tannins), polysaccharides, organic acids, essential oil, ascorbic acid, fatty acids, macro- and microelements, which provide its pharmacological effect.The antiulcer, hepatoprotective, membrane stabilizing, antioxidant, anti-inflammatory, analgesic, wound healing, hemostatic properties of LEFH were studied.It was found that LEFH at a dose of 20 mg/kg exhibits pronounced antiulcer activity in the model of gastric ulcer in rats caused by acetylsalicylic acid, and in the ethanol-prednisolone model of lesions of the gastric mucosa. All studies prove the prospects for further study of the Chamerion angustifolium extract in order to create drugs on its basis for the treatment and prevention of gastric ulcer.