Kovpak A. Experimental substantiation of optimization of treatment of arterial hypertension by combinations of ramipril and candesartan with corvitin

The dissertation is devoted to the peculiarities of the course of arterial hypertension in the model of experimental animals (rats of the SHR line) under the condition of treatment with ramipril and candesartan in combination with corvitin; for the first time the state of oxidative-antioxidant homeostasis and proteinase-inhibitory system in the experimental model of arterial hypertension was comprehensively analyzed; the state of separate factors of systems of hemostasis and fibrinolysis and their changes in experimental model of arterial hypertension is considered. The dissertation solves one of the key tasks of modern practical medicine - improving the treatment of hypertension by correcting the use of different groups of drugs, including angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers and the possibility of their combination with corvitin. The dependence of the state of oxidative-antioxidant homeostasis, proteinase-inhibitory system, hemostasis and fibrinolysis systems and their changes in the experimental model of arterial hypertension was studied. It was found that the use of ramipril in combination with corvitin has a pronounced systemic antioxidant protection and protection of target organs. The antioxidant effect of the combination is realized exclusively by the introduction of corvitin. The use of ramipril and candesartan in combination with corvitin in experimental hypertension has no gender differences