Tsemenko K. Experimental study of the pharmacological activities of ordinary lingonberry extracts (Vaccínium vítis-idaéa)

Based on the results of the screening studies, which included the study of new modified galenic and novogalenic phytosubstances from Vaccinum vitis ideae leaves, a leader phytosubstance was established, which is a complex of glycosides of phenolic compounds in combination with the amino acid arginine, which received the code name – СGPA and a conditionally therapeutic dose of this phytosubstance. The absence of toxic effects with single and multiple intragastric administration of СGPA has been proven. An in-depth study of the pharmacological properties of CGPA and its effect on the components of inflammation were provided and the mechanism of anti-inflammatory effect of CGPA was characterized. The analgesic activity of СGPA in the test "hot plate" and in the model of "acetic acid cramps" was established. It is assumed that peripheral and central components are involved in the implementation of the analgesic effect. It was found that there was no effect of СGPA on the behavior and vegetative manifestations of emotional reactions of animals in the "open field" test, and a mild anxiolytic effect in the "elevated plus maze" test. On the model of insulin resistance, the presence of the antihyperglycemic effect of СGPA was proved, which was confirmed by a possible decrease in the total area under the curve. On the experimental model of UTI, the presence of the uroantiseptic effect of СGPA was proved, which was confirmed by a significant decrease in colony-forming units of E. coli ATCC 25922 compared with the control pathology. In terms of the severity of the uroantiseptic effect, СGPA exceeded the reference drug Inurec and led to a more rapid decrease in colony-forming units in 1 ml of urine.