Ostapchuk O. Effect of antioxidants and omeprazol on antiinflammatory activity, side effects and pharmacokinetics of indomethacin.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U001163

Thesis Registration Form

0499U001163.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

19-05-1999

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

It is established that pharmacotherapy by indomethacin decreases the retinol and tocopherol level in blood plasma and damages the gastro-intestinal tract. Antioxidants aevit and selena reduce deficiency of vitamins, decrease ulcerogenal effect and increase the antiinflammatory activity of indomethacin. Omeprazol slows down the elimination of the unchanged form of indomethacin from blood plasma, increases the efficiency of antiinflammatory therapy and decreases the frequency of side effects on the gastro-intestinal tract. The introduction of principles of rational antiinflammatory therapy by indomethacin in clinical practice is carried out.

Read more

Similar theses

0422U100029

Sheikhali Ali Marsel

Experimental justification for the use of a new combined cream "Dermalipoin" for the treatment of purulent-inflammatory skin diseases

0422U100006

Dub Anastasiia Ihorivna

Experimental approach of the antidiabetic activity of the new phytocomposition

0421U102934

Stefaniv Ivan Volodymyrovych

Pharmacological characteristics of the new herbal medicine «Kasdent» for the treatment of inflammatory diseases of periodontium and oral mucosa

0421U102041

Prokopchuk Elena Gennadyevna

Complex compounds of Sn (IV) with salicyloylhydrazones of benzaldehydes as potential biologically active substances with anti-inflammatory, analgesic and concomitant pharmacological action

0521U101312

Nosivets Dmitriy Sergeevich

Pharmacological analysis of analgesia and chondroprotection in experimental osteoarthritis on the background of hypothyroidism