Marchyshyn S. Pharmacological Ground of Creation of New Medicinal Preparation on the Basis of Extract from Couch-grass Creeping

The pharmacological study of water extract from rhizomes and roots of couch-grass creeping (ERCC) and pills on its basis is carried out. It is established that ERCC in intragastric infusion in the dose of 100 mg/kg reveals expressive anabolic activity on intact animals and on model pathologies in violation of protein metabolism: food depravation, hydrocortisone inductive catabolism. The advantages of explored preparation and pills on its basis in comparison wit anabolic potassium action during tetracycline affection of liver, kidneys and adrenalin heart affection were discovered. Researches of anabolic action mechanisms permitted to determine the ERCC influence on nucleic acids synthesis and hormonal regulation of protein metabolism: testosterone lever was increased, thyroid activity was decreased. The lever of 11 oxycorticosteroids was increased due to ERCC. Inharmacodynamics study it was established that ERCC has a wide range of pharmacological activities: hepatoprotective action that was established on the model of tetrachlormethane hepatitis; antiallergic - that was established on the models of allergic reactions of immediate and slow type; antiinflammatory - on the model of caragenan edema. The extract of couch-grass creeping rhizomes and roots is "relatively harmless". It does not possess toxic action on animal's organs and systems during the study of chronic and specific toxicity. The extract of couch-grass is recommended as anabolic remedy in treatment of protein metabolism disorders which arise in many diseases. The investigated preparation is characterized by wide range of activity and is advantageous as for its economic characteristics.