Mikhalchuck V. The Role of Proteinases of Blood and their Inhibitors in the Mechanisms of Anti-influenza Defense

.The thesis is devoted to the study of the presence of the trypsin-like proteinases and their inhibitors in the blood of human donors, in industrial wastes of gamma-globulin, in commercial domestic preparations (immunoglobulin, interferon, vaccine for herpes and tularimia), in foreign preparations (anti-influenza vaccine - Influvac,Vaxigrір, Fluarix, vaccines for hepatitis A - Avaxim; preparations from blood - Fraxiparine, Solcoseryl). From the industrial wastes of gamma-globulin production they have selected isoform of trypsin-like proteinases with protective activity at infection of experimental animals with a lethal doze of A/PR/8/34 (А/Н1N1) grippe. It has been revealed: 1. Blood of donors, wastes of gamma-globulin preparation, anti-influenza vaccines and preparations of blood contain a great amount of trypsin-like proteinases; 2. They have got several isoforms inhibitors of trypsin-like proteinases from the wastes of gamma-globulin production; 3. Suppression of influenza infection under the action of the inhibitor's 5th isoform obtained from the first stage wastes of gamma-globulin production.