Mischenko O. Pharmacological activity and mechanisms of action of new class adaptogenes on basis of beekeeping products and succinic acid

The results of the work are experimental ground for new class adaptogenes development on basis of biologically active compounds of beekeeping products (bee pollen, phenolic hydrophobic propolis substantance) and succinic acid. The ability of preparations pollentar, phelentar, which contein succinic acid, to restore reaction of passive avoidance in conditions of retrograde and anterograde amnesia was established, it characterizes them as adaptogenes. The mechanism of pollentar actoprotective action consists in limitation of anaerobic metabolic processes, phosporilative process strengthening, organs carbohydrate reserve, lipid metabolism optimization, strengthening of protein synthetic processes, antioxidative defence increase and lipid peroxidation decrease. Under chronic stress conditions it was established that pollentar adaptogenic action was demonstrated both due to influence on neuroendocrine mechanism through hypotalamo-pituitry-adrenal system and due to peripheral components: protein synthetic processes strengthening as adaptation structural basis, energy storage optimization and lipid peroxidation-antyoxidative system balance restoring, that is due hydroxyl and superoxid radicals scavenging and radical generating enzyme хantinoxidasa inhibition