Konopkina L. Chronic obstructive pulmonary disease: role of inflammatory, diagnostic and treatment

Research subjects: chronic obstructive pulmonary disease (COPD). The aim of the investigation: to show the new mechanisms of formation, course and progress of COPD, to control the course of the disease by organisation of the system of long-term learning, monitoring and medical rehabilitation according to features of local and systemic inflammation. Methods: clinical, questionnaires, laboratories, functional, microbiological, bacteriological, immunological, statistical. Theoretical and practical results:clinical forms of COPD were defined. The spectr of microorganisms in stable phase and during acute exacerbation of COPD was leant. The conception of respiratory bacteriosis was offered. It was show the possibslity of control the course of the disease by organisation of the system of long-term learning, monitoring and medical rehabilitation in accordance with the features of local and systemic inflammation.The diagnostic and treatment of COPD patients in stable phase and during acute exacerbation were optimised. Novelty:the system of long-term learning, monitoring and rehabilitation of COPD patients was carried out. The group of high speed progress of COPD was determined. The algorithm of the treatment of COPD patients during non severe acute exacerbation and in the remote period depending on presence of low respiratory tract (LRT) bacterial colonization was proved. The influence of LRT bacterial infection/colonization on the level of systemic inflammatory markers was proved. It was shown the positive influence of prolong bronchodilators on systemic inflammation in COPD patients. Implementation: articles, theses, patent, field innovation, introductions into the teaching process at high medical schools. Area of application - pulmonology, therapy.