Vrynchanu N. Antimicrobial properties of new aminoadamantane derivatives and experimental justification for their medical use

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0510U000863

Thesis Registration Form

0510U000863.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

15-12-2010

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

As a result of screening assays of antimicrobial activity among new derivatives of aminoadamantane it was determined the most active substance 4- (adamantyl-1)-1-(1-aminbutil) benzole (AM-166) with a wide range of antimicrobial activity. AM-166 disrupts the structural organization of the external membrane of the microbial cell, achieves membranotropic action. According by obtained in vitro and in vivo data, 0.1% soft medicinal form (cream Adamicryn) is developed on the basis of substance 4-adamantyl-1)-1-(1-aminobutil) benzole. The cream Adamicryn reveals its effectiveness on the model of the local infectious process, caused both by monogerms and mixed infection. Due to antimicrobial properties and dehydrating action one can use the Adamicryn cream from the beginning of the 1 phase of wound process.

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