Khromov О. Experimental justification for application of phosphatidylcholine liposomes for correction of blood circulation disturbances in critical states

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0511U000412

Thesis Registration Form

0511U000412.pdf

Applicant for

Khromov Оlexandr Stanislavovich

Specialization

14.03.05 - Фармакологія

Date of defense

18-05-2011

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The thesis was designed to justify experimentally the phosphatidylcholine liposomes (PCL) application for correction of the pathological processes in critical states accompanied with hypoxia, cardiovascular disorders, endotoxemia and manifested in arterial hypotension. Only liposomes from egg phosphatidylcholine were proved to have a combined antihypoxic and antioxidant effects. In acute massive hemorrhage, PCL normalized the blood circulation and prevented the circulation centralization. PCL permitted to avoid the cardiac dysfunction and hypotension in septic shock. In myocardial ischemia and reperfusion, PCL had a cardioprotective and antiarrhythmic effect. PCL normalized an energy metabolism in the cardiomyocytes and an electrical stability in the myocardium. In the endogenous intoxication syndrome, PCL provided a detoxication.

Thesis supervisor

Solovyev Anatoliy Ivanovich

Official opponents

Мохорт Микола Антонович
Горчакова Надія Олександрівна
Бобирьов Віктор Миколайович

Files

DIS--Благодарности.doc

DIS--Введение.doc

DIS--Выводы.doc

DIS--Приложение А.doc

DIS--Приложение Б.doc

DIS--Раздел1.doc

DIS--Раздел2.doc

DIS--Раздел3.doc

DIS--Раздел4.doc

DIS--Раздел5.doc

DIS--Раздел6.doc

DIS--Раздел7.doc

DIS--Раздел8.doc

DIS--Список литературы.doc

автореферат.doc

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