Kovalenko V. Theoretical and scientist justification of development and using complex disinfectants for veterinary medicine.

Development, studying and application of the effective complex chemical compounds for prevention of animal infectious and parasitic diseases in Ukraine were the main focus of this dissertation. Based on the completed theoretical studies it was identified that in order to improve complex activity of disinfectants it is necessary to ensure during manufacturing synergic action of both chemical compounds with different vectors of activity by stabilizing gradients of new component chemical potentials. These compounds have wide spectrum of action and prevent practically and scientifically important for veterinary medicine animal poisoning and environmental pollution. Methodological complex approaches have been developed for evaluation of the effect of disinfectants on immune system taking into account potential risks for immune system during development and application of disinfectants. Recipes for disinfectants diamant with insecticidal, acaricidal properties as well as sriblobenz and silver-copper colloidal solution with bactericidal properties were developed. By using cultures of E. coli and S. aureus, virus of La-Costa of New-Castle poultry disease and fungi Aspergillus, Penicillium, Fusarium disinfectant's effective concentrations for effective disinfection were identified in manufacturing conditions. In order to identify sensitivity of micromicetes to test compounds serial dilutions of compounds, method of paper discs as well as method of diffusion into agar were the main methods used. Effective concentrations as well as duration of their insecticidal action were also identified. Safety of disinfectants diamant, sriblobenz and silver-copper colloidal solution was shown and confirmed.