Gorbacheva S. Role of correlation between thiol-disulfide system and nitric oxide in mechanisms of neurons persistence in conditions of cerebral ischemia

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0516U000817

Thesis Registration Form

0516U000817.pdf

Applicant for

Gorbacheva Svitlana Vasilivna

Specialization

14.01.32 - Медична біохімія

Date of defense

06-10-2016

Specialized Academic Board

Д 29.600.03

Essay

In the given dissertation it was pioneered a theoretical and experimental generalization of combined system "nitric oxide/reduced thiols" in a pathogenesis of ischemic neurodestruction and also the solution of scientific problem concerning treatment of acute impairments of cerebral circulation by means of pharmacological modulation of glutathione-mediated links of endogenous neuroprotection and neuroplasticity. The obtained interconnection of an expression of endogenous cytoprotection factor HSP70 with the disturbances in functioning of thiol-disulfide system glutathione link can be one of the possible mechanisms of neuroprotective action of thiol-disulfide system modulators.

Thesis supervisor

Belenichev Igor Fedorovich

Official opponents

Клімочкіна Олена Михайлівна
Калінін Ігор Васильович
Малоштан Людмила Миколаївна

Files

aref.doc

dis.doc

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