Tsyryuk O. Mechanisms of gastric secretory system functioning in conditions of prolonged hypergastrinemia

Dissertation is dedicated to investigation of mechanisms of gastric secretory system functioning in conditions of prolonged, omeprazole induced, hypergastrinemia. The results showed that due to hypergastrinemia and dysbiosis, that developed during prolonged hypochlorhydria, structural and functional changes in ras't gastric secretory system appear. It was shown dynamic of hypergastrinemia development and its effect on basal gastric secretion through different periods of omeprazole administration. It was determined that 28-days long hypochlorhydria causes multidirectional changes in basal acid output and decrease parietal cells' sensitivity to stimulants of gastric secretion such as pentagastrine and histamine. It was shown that long term hypergastrinemia causes dysregeneratory changes in the gastric mucosa, activates collagenolytic processes, enhances depolymerization of fucoproteins, glycosaminoglycans of connective tissue and protective proteins of mucosa. Lectin histochemical studies had shown that hypergastrinemia leads to disruption of adhesive intercellular interactions, synthesis of carbohydrate components of cell surface and intracellular compartments. In dissertation possible ways of correction of negative effects of prolonged hypergastrinemia were suggested with use of following substances: proglumide, verapamil, PPAR? agonists (pioglitazone, melanin) and multiprobiotics of Symbiter group.