Objects – silver, gold and copper nanoparticles and compositions of these nanoparticles with antimicrobial agents, obtained by two methods: electron beam nanotechnology method developed by the laboratory of "Electron-beam nanotechnology of inorganic materials for medicine" of E. O. Paton Electric Welding Institute and method of colloid-chemical synthesis in the F.D. Ovcharenko Institute of Biocolloidal Chemistry NAS of Ukraine, excipients; aim – theoretical, methodological and experimental substantiation of pharmaceutical development of antimicrobial drugs in various dosage forms based on metal nanoparticles as active pharmaceutical ingredients, study of their physicochemical, pharmaco-technological properties, influence of auxiliary substances, dosage forms and technological methods on biological release also toxicological and pharmacological properties; methods – general scientific, organoleptic, physicochemical, identification and quantification, pharmacological, microbiological, biological, mathematical; novelty – the scientific provisions of pharmaceutical development of drugs based on metal nanoparticles as active pharmaceutical ingredients and compositions of these nanoparticles with antimicrobial agents were substantiated; composition, rational technology and standardization methods of new antimicrobial drugs based on silver, gold and copper nanoparticles in different dosage forms were substantiated; physicochemical and pharmaco-technological properties of nanomaterials and developed drugs based on them were studied; application of atomic absorption spectrometry using the method of standard additions for quantitative determination of metal nanoparticles is substantiated; the methodology of development of quality control methods of nanocomposites of metal nanoparticles with antimicrobial agents was proposed, the possibility of using pharmacopoeial methods of analysis of metronidazole and levofloxacin for their compositions with silver nanoparticles was substantiated, and the methods of quality control of the used active pharmaceutical ingredients and dosage forms were elaborated; prospect of use of silver nanoparticles as a new preservative in the composition of soft drugs has been proved; draft of general pharmacopoeial article "Drugs with metal nanoparticles" was developed; antimicrobial activity and safety of used active pharmaceutical ingredients and developed medicines based on them are confirmed; results – medicines based on silver, gold and copper nanoparticles in various dosage forms - ointment, cream, gel, tablets, syrups, solution for wound cleansing and eye drops were developed and tested, drafts of technological regulations and methods of quality control for dosage forms have been developed; introduced - testing in the conditions of industrial production, into the scientific process of higher education institutions; branch - pharmacia.