Profatylo A. Features of the inflammatory response against the background of microbiome disorders in newborns with neonatal encephalopathy.

At the beginning of the study, 119 children (age from 8 to 35 days) were examined, of which 87 were newborns with neonatal encephalopathy (NE) and 32 practically healthy children, who formed the control group. Depending on the course of NE and the method of treatment, the children were divided into 2 groups and 4 subgroups. The first group consisted of 66 children with NE 2 (moderate) degree, the second group consisted of 21 newborns with NE 3 (severe) degree. Each of these subgroups was divided into 2 subgroups depending on the appointment of a probiotic to the standard treatment. Also, 2 groups were additionally selected among all children with neonatal encephalopathy, which were divided depending on the presence of probiotic therapy. Risk factors for the development of neonatal encephalopathy in newborns were determined. The clinical and anamnestic features of the course of neonatal encephalopathy of various degrees of severity have been established. An analysis of changes in indicators of the intestinal microbiome (Bifidobacterium, Lactobacterium, Escherichia coli, Opportunistic pathogenes), local inflammatory response (fecal calprotectin), systemic inflammatory response (C-reactive protein, interleukins 1β and 10) was performed. The relationship between the detected changes in the values of the intestinal microbiome, local and systemic inflammatory response was investigated. The level of the inflammatory process in newborns with neonatal encephalopathy was estimated using the created mathematical prognostic model. The work substantiates the improvement of the diagnosis and control of the therapy of newborns with neonatal encephalopathy based on the study of the features of the systemic and local inflammatory response.