Ovcharenko N. Experimental pharmacokinetics of cinazepam and its metabolites

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U002808

Thesis Registration Form

0406U002808.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

07-06-2006

Specialized Academic Board

Д 41.600.01

Odessa National Medical University

Essay

In in vitro experiments there was shown the intensive metabolism for cinacepam, during which its main metabolite – norcinazepam, glucuronic conjugates and nonhydrolized water-soluble metabolites are formed. The main metabolism ways in vivo and in vitro are similar. After intravenous administration cinazepam is excreted from organism at 4 %, after oral administration from, – at 10 % of administered dose The rest are glucuronic and non-hydrolized conjugates. On the base of “dose-concentration-pharmacological action” dependence cinazepam is concluded to be a prodrug, witch pharmacological action is determined with norcinazepam presence. The norcinazepan itself is easyly absorbed after oral and transdermal administrations at relatively low biotransformation level (unchanged substance is excreted at 17 % after intravenous administration and 30 % after transdermal.

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