Toryanik E. 2-oxoindolin 3-glioxil acid derivatives - of antihypoxic acid-potential antioxidants

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U000382

Thesis Registration Form

0407U000382.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

17-01-2007

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

There has been revealed acute toxicity of 23 new derivatives of 2-oxoindolin 3-glioxil acid which is within the range of 400mg/kg upto 3750 mg/kg animal body weight thus ranking them among low-toxic and completely nontoxic substances, i.e. of V and VI toxicity class according to K.K. Sidorov's classification. ЛД50. Oxoindolin normalizes electrocardiography and cardiohemodynamics; considerably arrests the formation both of primary and secondary products of free-radical oxidation. Oxoindolin contributes to the acceleration of macroergenic linkage by miocardiac cells, thus excluding any macroergenic reserve depletion (? ATF + ADF + AMF was increased by 35 percent compared with these factors observed in animals which did not undergo any treatment).

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Files

AREF.DOC

dis.doc

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