Lonska O. An experimental research of actoprotective activity of the new adamantane derivatives

New derivatives 1-adamantylethyloxy-3-dialkilamino-2-propanol in dozes making 1-6 % from their LD50 can raise physical serviceability (actoprotective action) on models of different extreme states (hypo- and hyperthermia, haemic and circular hypoxya, hypokinesia) of rats. The compound with the laboratory code UK-1 (1-adamantylethyloxy-3-morpholino-2-propanol hydrochloride, ademol) showed the greatest degree of the actoprotective activity. Ademol was comparable and sometimes it surpassed actoprotector bemithylum sample in the size of the specified action on the majority of the used models of physical loading. Researched adamantane's derivatives are also carrier of antihypoxyc activity. The 15-day's introduction in rat's organism of compound UК-1 (2,8 мg/kg), as well as bemithylum (33,5 мg/kg), on a background of daily trainings (running test) was accompanied with stimulation of synthesis RNA and DNA, reduction of presentations of energy deficiency, preservation of carbohydrates reserves and normalization of parameters of prooxydation-antioxydation balance in rat's blood, liver and skeletal muscles. Daily introduction to rat's organism of compound UК-1 (2,8 мг/kg), like bemitilum (33,5 мг/kg), in conditions of 15-day's hypokinesia on the data of morphological research promoted reduction of attributes dystrophic and strengthening of regeneration processes in a liver, heart, kidneys, epinephros and skeletal muscles.