Prepodobnya K. Mechanisms of elimination and metabolism of gidazepam in rat organisms

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U000111

Thesis Registration Form

0409U000111.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

17-12-2008

Specialized Academic Board

Д 41.600.01

Odessa National Medical University

Essay

The work is dedicated to studying of elimination and metabolism of gidazepam and its metabolites from the organism’s of experimental animals. Using the combination of thin-layer chromatography and mass-spectrometry was established the structure of gidazepam and its metabolites. Under in vivo experiments the intensive metabolism of gydazepam, forming the main metabolites – dealkilgydazepam, dealkilhydroxygydazepam and acetylhyrozine were detected. The hydrolytic/lipophylic metabolites were 6:1. By the help of standard methods of inhibition analysis the different CYP450 izoforms, participating N1-dealcylation and C3-hydroxylation were excluded from gydazepams’ metabolism. This can be used for cross influence after concomitant CYP450 inhibitors or inductors administration.

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Files

Dis.doc

aref.doc

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