Dissertation is devoted to the study of uveitis caused by babesiosis in dogs. Babesiosis uveitis in dogs more often develops in Eastern-European sheepdogs (27,8 %), more rarely in mongrel dogs (16,7 %); the most often it develops in dogs over 12 months of age (58,8 %), probably the disease is caused by increase of sensibilization due to the age. In case of light inflammation of the ciliary body miosis, photophobia, lacrimation and insignificant changes of the iris are noted; in case of moderate stage of impairment marked miosis, some ciliary tenderness, edema of the cornea and iris, precipitates in the front chamber of the eye are expressed; in case of severe ciliary inflammation pericorneal injection of the vessels, hyphema, severe tenderness in the area of ciliary body, fibrin in the front chamber of the eye, posterior synechias and glaucoma occur. Сontent of erythrocytes, hemoglobin, leucocytes, indices of leukogram, contents of proteins, its fractures, bilirubin, AST and ALT, urea and creatinine in the blood in case of babesiosis not complicated with uveitis are identical to babesiosis indices complicated with uveitis. This points to the pathogenetic role of other causes of origin of inflammation of ciliary body. Count of leukocytes, lymphocytes, T- and B-lymphocytes, T-helpers, T-supppressors, immunoregulating index, content of Ig G, A, M in babesiosis complicated with uveitis are reliably higher as compared with babesiosis not complicated with uveitis. This determines pathogenetic role of immunologic disorders in the origin of inflammation of ciliary body. Formation of immune complexes, especially fine-molecular ones (< 15 S) on a background of decrease of phagocyte activity leads to sedimentation of immune deposits in the developed uveal vessels with the following inflammation of ciliary body and exudation into the eye chambers. This is confirmed by cytologic investigations. A rational treatment of babesiosis uveitis involves comdined usage of mydriatics (more often it is 1% atropine solution), NSAIDs, diclofenac in the dose of 0,5 mg/kg, thymalin (as an immunomodulator and phagocytosis stimulator) in the dose of 5-20 mg/kg of body mass of the animal in relation to the severity of inflammation of eyeball vascular membrane as antibabesiosis therapy.
