Klekot O. Clinico-pharmacological interaction of propofol and analgetic with modificators of microsomal monooxygenaz (clinical-experimental research)

In the clinical follow-up found that the usage of traditional therapy of pulmonary arterial hypertension (PAH) in systemic lupus erythematosus (SLE) by glukocorticoids and nonsteroidal anti-inflammatory drugs is insufficient and ineffective. Adding to the traditional basic therapy of SLE L-arginine-containing drug, NO donator сorargine within 8-th weeks led to decreasing of systolic pressure in pulmonary circulation, improving clinical, functional and hemodynamic parameters in PAH, reducing inflammatory activity and the correction of endothelial function, thus increasing the level of active NO deposited in the thiol compounds of blood. Independent predictors of hypotensive efficacy of сorargine were: the age of patients more then 50-th years old, longitudinal period of Gk usage, initial level of systolic blood pressure in pulmonary artery less then 60 mm Hg, low concentration of blood thiols and decreased of endothelium-dependent vasodilation in hyperemia test. The effectiveness of сorargine in patients with SLE-PAH was higher, then effectiveness of reference drug – amlodipine.