Klimenko O. Experimental substantiation of metabolitotropic preparations effectiveness under haemic and hystotoxic hypoxia

Cardiothryl and its active metabolite belong to the class of organic compounds, heterocycles, the 6?-electron aromatic systems. There are 112 molecular orbitals in the cardiotryl molecule. There are 69 molecular orbitals in molecular of MT. The most negative charges of cardiotryl are defined, which localized on the atoms N (18), N (10), N (15), N (12), C (2). It is found that the greatest electron density is observed for atoms N (10), N (11), N (12), N (15), N (18). The most negative charges are established for atoms N (1), N (2), N (4), N (6), C (8) in molecular of MT. All nitrogen atoms have the largest electron density and negative electrostatic potential. Obtained data confirm the presence of antihypoxic activity under haemic and histotoxic hypoxia in the ATP-long and 1,2,4 - triazole derivatives (cardiothryl and MT). The mechanism of antihypoxic action is: ATP-long affects on the processes of synthesis and energy transfer, normalizes prooxidant-antioxidant homeostasis and RNA content in the nuclei; cardiothryl and mainly MT, besides above-mentioned mechanisms, implement its antihypoxic activity through the influence on thioldisulfide system, transport system NO, protein synthesis and aerobic glycolysis.