Volska A. Experimental rationale for prevention of hepatotoxic action of paracetamol by Thiotriazoline

The investigation is devoted to effectiveness of Thiotriazoline against experimental liver damage caused by paracetamol. During experimental studies it was found that acute liver damage caused by paracetamol at various stages (3, 8 and 15 days) accompanied by an increase of pro-oxidant balance / antioxidants, increased concentrations of IL-1? and decrease in IL-10 content, increased activity of aminotransferases and alkaline phosphatase, content of molecules of moderate mass in blood serum, prolongation sleep duration caused by thiopental, decrease in the activity of reactions of the 1st stage biotransformation of xenobiotics, development of morphological signs of liver damage. For the first time it was proved the effectiveness and feasibility of Thiotriazoline administration for effective prevention of hepatotoxic effects of paracetamol. Its activity is evidenced by renewed balance between interleukins IL-1 and IL-10, positive dynamics of cytolysis, cholestasis, levels of endogenous intoxication, increased antioxidant protection, increased activity of reactions of xenobiotics biotranspformation in liver, marked improving in liver histological structure as a result of Thiotriazoline application, compared to the group of animals in which the correction was not performed. Thiotriazoline positive impact on the state of the liver in its acute lesions with paracetamol manifested more than acetylcysteine.