Saenko A. Actoprotective properties of the new derivatives of 1,2,4-triazine-quinazolin (experimental study)

It was established that intra-abdominal administration of the new derivative of 1,2,4-triazine-quinazolin of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4] triazine [2,3-c] quinazolin-6-yl) propanoic acid (MT-279 compound, 5 mg/kg) as well as Bemithylum (25,0 mg/kg) to rats led to increase of their physical endurance (according to the swimming test data) that proved the actoprotective activity of these substances. The actoprotective effect of MT-279 compound evidently manifested itself both under ordinary and complicated conditions of the experiment (hypo- and hyperthermia, hemic and circulatory hypoxias, hypokinesia). And in terms of the stated effect MT-279 compound equaled and sometimes exceeded the reference actoprotector Bemithylum. The mechanism of the actoprotective effect of МТ-279 compound is connected with its antihypoxic (anti-ischemic) activity, ability to stimulate the non-specific protein synthesis (RNA, DNA) in the liver, energy supply of the working muscles (increase of the amount of ATP and energy), prevention of negative changes in the prooxidant-antioxidant system (decrease of MDA level, increase of the reduced glutathione).