Herashchenko I. The study of tocolityc effect derivatives of bromide 1,3-diaryl-3-hydroxy-2,3,6,7,8,9-hexahydro-5H-imidazo[1,2-a]azepine

The dissertation is based on the experimental research of tocolityc effect of new synthesized derivatives of bromide 1,3-diaryl-3-hydroxy-2,3,6,7,8,9-hexahydro-5H-imidazo[1,2-a]azepine with previously predicted spectrum of pharmacological action by using the PASS program. In this study we investigated the effects of the derivatives of bromide 1,3-diaryl-3-hydroxy-2,3,6,7,8,9-hexahydro-5H-imidazo[1,2-a] azepine on oxytocin-induced contractions in the rat uterus in vitro and ATPases activity in myometrium cell's plasma membrane. Contractile activity was studied isometrically and analysis of contractions was performed by the calculation of the basal tone, amplitude, interval between cycles of reduction, the phase of contraction and relaxation. The derivatives of bromide 1,3-diaryl-3-hydroxy-2,3,6,7,8,9-hexahydro-5H-imidazo[1,2-a]azepine IFT_000176, IFT_000208 activate Ca2+,Mg2+-ATPase and inhibit Na+,K+-ATPase. The inhibition uterine horn's muscle stripes contractions caused by oxytocine may be due to Ca2+,Mg2+-ATPase activation. It is bloks one biochemical pathway influence oxytocine on calcium homeostasis of myometrium.