Tattis A. Experimental study of pharmacological properties of the "Altsinara" drug

The dissertation is devoted to the experimental substantiation of expediency of application of the new combined plant drug "Altsinara" in medical practice. It has been proved that "Altsinara" is a practically safety drug that almost does not exert a toxic effect on the body, not only with a single dose, but also with long-term use in ultrahigh doses. In the study of lipid-lowering action of "Altsinara" on the model of "twin" hyperlipidemia in rats found that it conditionally effective dose is 100.0 mg/kg. In-depth study of lipid-lowering properties of "Altsinara" on course "vitamin" hyperlipidemia in rats in dose 100.0 mg/kg showed the positive impact that this action is due to a complex product that is associated with the presence of not only hypolipidemic and antiatherogenic activity, but antioxidant, antihypoxic, endotheliumprotective and antiplatelet properties. It was determined that the rate of "Altsinara" ED50 for hepatoprotective activity on the model of acute tetrachloromethane hepatitis in rats is 59.6 8.3 mg/kg by the amount of active ingredients, confirmed pronounced anticytolytic and antioxidant effects on the development of this pathology. According to the results of the choleretic activity study of "Altsinara" should be considered as a true choleretic that enhances the formation of bile primarily by stimulating the synthesis of primary bile acids, as evidenced by the likely increase of cholatocholesteric coefficient. (ED50 for choleretic activity was 72.4±11.0 mg/kg by the amount of active ingredients). In the therapeutic and prophylactic application at a dose of 60.0 mg/kg, the drug "Altsinara" had a complex positive effect on the course of tetrachloromethane-ethanol hepatitis in rats, which was manifested in a possible decrease in the intensity of the cytolytic and cholestatic processes. The obtained results substantiate the necessity of using the study drug in clinical practice as a hypolipidemic, anti-atherogenic, hepatoprotective and choleretic agent