Object of study: processes of creation, accumulation and prevent loss of human capital at the macro, meso, micro and personal level. Objective: developing the theoretical and methodological, scientific and methodological foundations of the study of human capital loss, such loss evaluation and justification of conceptual directions to prevent them. Methods: historical and logical, analytical and synergistic, dialectical logic, induction, deduction, comparative, multidimensional and statistical analysis, peer review, economics and mathematical modeling, graphical and analytical. Novelty: the first formed the theoretical and methodological basis of the new trend of social economy, which features the author's theory of the development of human capital losses presented in the form of synthesized based provisions designed Concept prevent loss of human capital of Ukraine, whose aim is the quantitative and qualitative reduction of their actual and potential volume for basis sociohumanistic paradigm of social life, reasonably substantial nature of the category "loss of human capital" and reveals its definition as a socially unfavorable reduction of human capital, the classification factors loss of human capital with the release of aggregated complexes (demographic, socio-demographic, economic, socio-economic, socio-political, environmental, psychological). Scope: in the activities of the Ministry of Economy of Ukraine in the development of measures to improve the management of the central government socio-economic development of the country and its regions in improving the functioning of the demographic subsystem in the post-crisis period, the State Inspection of Ukraine on protection of consumer rights, Lviv Regional Employment Centre for the justification in terms of the number of unemployed in the employment preparation program for 2012-2014 biennium, Main Department of Economics of Ternopil Regional State Administration in terms of evaluation of media losses of human capital, in the learning process of the Lviv Academy of Commerce, Lviv Institute of Economy and Tourism, Lviv Branch of European University.